Abstract: Background：Patients with congenital heart disease need lifelong followup, and lack of disease knowledge may lead to interruption of followup. Effective assessment of patients' and caregivers' disease knowledge and accurate education can reduce unintended complications and facilitate their transition to adulthood. Objective：To translate English Leuven knowledge questionnaire for congenital heart disease (LKQCHD) into Chinese version,and explore its application effect in parents of CHD patients. Design：English to Chinese translation and a crosssectional survey. Methods：After permission from the original author, a new Brislin translation model was applied to translate English LKQCHD into Chinese through literal translation, back translation and contrast back translation. A content validity evaluation was conducted by 7 healthcare experts. After confirming the content and face validity of the questionnaire, the LKQCHD was distributed to parents of CHD patients. Logistic regressive analysis was performed to investigate the factors influencing the disease knowledge of parents of CHD children. Main outcome measures：Disease knowledge questionnaire scores. Results：The Chinese version of LKQCHD contained 27 items. The item content validity index（ICVI）was 0.97 , the universal agreement of scale level content validity index（SCVI/UA）was 0. 85，the mean scale level content validity index(SCVI/AVE) was 0.97, and the interrater agreement（IR）was 0.85. A total of 302 Chinese version LKQCHD questionnaires were send out and taken back 301 effective questionnaires with the accuracy of (65.2±23.5) %. Multivariate analysis showed that the mother's education level, the family's economic level and the times of surgeries were the main influencing factors of the score of LKQCHD. Conclusions：The Chinese version of the LKQCHD is valid to assess the level of knowledge mastery in parents and caregivers of CHD patients.

Key words: Congenital heart disease, Knowledge questionnaire, Translation, Validity