中国循证儿科杂志 ›› 2019, Vol. 14 ›› Issue (6): 457-459.

• 论著 • 上一篇    下一篇

C反应蛋白在婴儿泌尿系感染中的诊断价值

王利霞1, 2,马丽娟1, 2,张宏文1   

  1. 1 北京大学第一医院儿科 北京,100034;2 宁夏回族自治区妇幼保健院(宁夏儿童医院)儿科  银川,750002
  • 收稿日期:2019-07-25 修回日期:2019-12-17 出版日期:2019-12-25 发布日期:2019-12-25
  • 通讯作者: 张宏文
  • 基金资助:
     

Diagnostic value of CRP on urinary tract infections in infants

WANG Li-xia1, 2, MA Li-juan1, 2, ZHANG Hong-wen1   

  1. 1 Department of Pediatric, Peking University First Hospital, Beijing 100034, China; 2 Department of Pediatric, Ningxia Maternal and Child Health Care Hospital & Ningxia Children's Hospital, Yinchuan 750011, China
  • Received:2019-07-25 Revised:2019-12-17 Online:2019-12-25 Published:2019-12-25
  • Contact: ZHANG Hong-wen
  • Supported by:
     

摘要: 目的 探讨C反应蛋白(CRP)在婴儿泌尿系感染诊断中的价值。方法 回顾分析2015年1月1日至2017年12月31日儿科门诊以发热为首发症状就诊的婴儿,病初有血常规和CRP检查结果且CRP>8 mg·L-1者,最终诊断明确为细菌感染者(包括呼吸道感染、消化道感染、泌尿系感染和中枢神经系统感染),根据CRP(mg·L-1)数值分为A组(8~25)、B组(25~50)、C组(50~75)、D组(75~100)和E组(≥100),比较不同组的诊断情况。结果 713例婴儿纳入研究,其中A、B、C、D和E组分别为320、216、84、58和35例。随着CRP的升高,泌尿系感染所占比例升高,而呼吸道感染和消化道感染所占比例降低。当CRP≥50 mg·L-1时,泌尿系感染阳性率62.1%(110/177);当CRP≥75 mg·L-1时,泌尿系感染阳性率87.1%(81/93);而当CRP≥100 mg·L-1时,泌尿系感染阳性率高达91.4%(32/35)。当CRP≥50 mg·L-1时,约登指数最大(0.819),敏感度93.2%(95%CI:86.6%~96.8%),特异度88.7%(95%CI:85.9%~91.1%)。结论 凡是婴儿发热,特别是血常规CRP明显升高者(≥50 mg·L-1),在应用抗生素之前必须完善尿常规检查,以明确或除外泌尿系感染可能。

 

Abstract: Objective To explore the diagnostic value of C-reactive protein (CRP) on urinary tract infections (UTI) in infants. Methods According to the level of CRP, the clinical data of outpatient infants with fever, who were first visited in our hospital from January, 2015 to December, 2017 were studied retrospectively. They were diagnosed clearly and divided into five groups including A(CRP<25 mg·L-1)、B(25≤CRP<50 mg·L-1)、C(50≤CRP<75 mg·L-1)、D(75≤CRP<100 mg·L-1)and E(CRP≥100 mg·L-1), respectively. Results 713 cases of infants with fever were included finally in the study, and group A, B, C, D and E consist of 320, 216, 84, 58 and 35, respectively. With the level of CRP increasing, the percent of UTI also increased. When CRP≥50 mg·L-1, ≥75 mg·L-1 and ≥100 mg·L-1, the percent of UTI was 62.1% (110/177), 87.1% (81/93) and 91.4% (32/35), respectively. When CRP ≥50 mg·L-1, Youden index was the most with 93.2% sensitivity(95%CI: 86.6%-96.8%) and 88.7% specificity(95%CI: 85.9%-91.1%) Conclusion Routine urianalysis must be down in order to exclude or identify the diagnosis of UTI in infants with unknown fever and obviously increased CRP (≥50 mg·L-1).

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