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Chinese Journal of Evidence -Based Pediatric ›› 2016, Vol. 11 ›› Issue (4): 241-246.

• Original Papers •     Next Articles

Nasopharyngeal carriage rate, serotype distribution and antibiotic resistance pattern of Streptococcus pneumoniae isolates collected from hospitalized children with respiratory tract infections in a single-center grade two hospital in western of China: a cross-sectional study

CHEN Chang-hui1,4，SHI Wei2,4,PENG Yong-jun1,XIONG Wei1,YUAN Lin2,GAO Wei2,CHENG Xiao-ping3,YAO Kai-hu2   

  1. 1 Department of Pediatrics, Youyang Hospital, The First Affiliated Hospital of Chongqing Medical University; People′s Hospital of Chongqing Youyang County, Chongqing 409899; 2 Key Laboratory of Major Diseases in Children, Ministry of Education, National Key Discipline of Pediatrics (Capital Medical University), National Clinical Research Center for Respiratory Diseases，Beijing Key Laboratory of Pediatric Respiratory Infection Diseases, Beijing Pediatric Research Institute, Beijing Children′s Hospital affiliated to Capital Medical University, Beijing 100045; 3 Department of Clinical Laboratory, Youyang Hospital, The First Affiliated Hospital of Chongqing Medical University; People′s Hospital of Chongqing Youyang County, Chongqing 409899; 4 co-first authors
  • Received:2016-06-25 Revised:2016-08-29 Online:2016-08-25 Published:2016-08-25
  • Contact: CHENG Yi-ping,YAO Kai-hu

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Abstract:

Objective To investigate the status of nasopharyngeal carriage rate, serotype distribution and antibiotic resistance pattern of Streptococcus pneumoniae isolates collected from children with respiratory tract infections inpatiented in Youyang county.Methods The nasopharyngeal swab was collected from children with respiratory tract infections inpatiented in People′s Hospital of Chongqing Youyang County from January to December in 2015. The serotype was determined by Quellung reaction, and the antibiotic susceptibility was tested by E-test method and disc diffusion.Results The nasopharyngeal carriage rate of Streptococcus pneumoniae was 25.3% (267/1054), major in winter and spring among children younger than 5 years old. Serotype 19F(47, 17.6%), 6A(35, 13.1%), 14(31, 11.6%), 19A(28, 10.5%), 23F(28, 10.5%) and 6B(25, 9.4%) were the common serotypes, and the coverage rate of 13-pneumococcal conjugate vaccine (PCV13) was 73.8%(197/267). All of the isolates were sensitive to ceftriaxone, vancomycin and levofloxacin. The sensitive rates to linezolid, imipenem and telithromycin were 96.3%, 87.5% and 84.5%, respectively. All of the isolates were sensitive to penicillin using the parenteral breakpoints, but the sensitive rate was just 16.9% according to the oral breakpoints. 99.3% (135/136) of the isolates were resistant to erythromycin and azithromycin. The non-suscepibility rates to oral penicillin, cefepime, cefuroxime and imipenem were higher in PCV13 isolates than non-PCV13 isolates (P<0.01). Isolates of serotype 19A were more resistant than the other serotype isolates.Conclusion The nasopharyngeal carriage rate of Streptococcus pneumoniae was 25.3%, the common serotypes were 19F, 6A, 14, 19A, 23F and 6B. PCV13 coverage rate was high, and the non-suscepibility rates to oral penicillin, cefepime, cefuroxime and imipenem were higher in PCV13 isolates than non-PCV13 isolates.